The increasing deployment of digital health technologies, rising R&D activities, and integration of telehealth into healthcare services are fueling the rapid expansion of the virtual clinical trials market. The evolution of mobile and wearables, AI, cloud computing, and data platforms is changing clinical trials by making data collection more accurate, frequent, and multi-dimensional. This change has been ensuring the development of new, innovative trial designs. Patient recruitment and retention along with experience are made better through virtual trials. Virtual clinical studies also ensure the establishment of novel endpoints in clinical studies. Virtual trials allow the participant to participate remotely because they allow greater inclusivity. They reduce site visits hence improving patients\' recruitment and retention rates. The use of wearables directly connected to the smartphone of the patient enhances the real-time collection of data and makes direct communication possible, thereby enhancing the engagement of patients and reducing the burdens on the participants and CRCs.