While not a cure, the best supplements for kidney health can support overall kidney function and mitigate the effects of PKD.Polycystic Kidney Disease (PKD) is a genetic disorder characterized by the growth of numerous fluid-filled cysts in the kidneys. These cysts can gradually enlarge, causing the kidneys to grow abnormally large while losing their ability to function effectively. PKD is a serious condition that can lead to kidney failure if not managed properly.