The rapidly growing cannabis industry faces unique challenges in distribution logistics due to stringent regulations, security concerns, perishability, and market fragmentation. Compliance is critical, requiring robust systems to track and document processes while adhering to local, state, and federal laws. Blockchain technology can enhance transparency and ensure immutable compliance records. Security measures, such as GPS tracking, secure vehicles, surveillance, and employee background checks, are vital to protecting high-value cannabis products from theft and diversion. Proper storage and handling, including temperature-controlled environments, ensure product quality and safety throughout the supply chain. Advanced logistics software can optimize routes, manage inventory, and streamline deliveries, while vertical integration reduces complexity and improves coordination. To address scalability and market fragmentation, companies must adopt adaptable logistics strategies, leverage centralized data management, and invest in automation and scalable infrastructure. By overcoming these logistical hurdles, the cannabis industry can ensure efficient, secure, and compliant distribution, supporting sustainable growth and success.