Choosing the right framework for hybrid mobile app development is crucial for performance and user experience. Popular options include React Native, Flutter, and Ionic, each suited to different needs. React Native, ideal for real-time updates, uses JavaScript for native performance. Flutter, known for rich UI and high-quality graphics, suits complex designs, while Ionic is straightforward to integrate with web technologies like Angular and is ideal for simpler, budget-friendly apps. Selecting the right framework depends on app complexity, team expertise, and project goals.