How to Synthesize 4-Bromo Orthocresol
4-Bromo orthocresol can be synthesized through the bromination of orthocresol (2-methylphenol). In this reaction, bromine is added to the aromatic ring in the presence of a suitable solvent like acetic acid or carbon tetrachloride. Due to the activating effect of the hydroxyl and methyl groups, bromine selectively attaches to the para position relative to the hydroxyl group. The process is controlled to avoid multiple substitutions, yielding 4-bromo orthocresol efficiently.