The market for genomics services is highly on a growth trajectory that is fueled by increasing demand for personalized medicine, gene therapy, and drug discovery and the rising prevalence of cancer, as well as the increasing popularity of consumer genomics. Next-generation sequencing and microarrays have indeed revolutionized the technological aspects of the field to generate massive amounts of genomic data. However, the bursts of data collected from such sources, together with that which originates from DNA sequencing and EHRs, present challenges while offering opportunities to derive clinically relevant insights from them.